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I put the monthly dose of frontline on both my dogs the other day. You have to empty the vial on the neck next to the skin near the collar. My dogs will sit still for this but you can tell in their eyes they feel anxious. As soon as I turn them loose, both dogs will run and rub their necks and body against the carpet. It must itch. Its only a few minutes they do this. Then they will settle down. Frontline is the best flea medication I have used. I wont use anything else. Since I started using Frontline, I have not seen a flea in my house. I have visited my daughter who had several cats and didn’t use the flea medication. I couldn’t sit on her couch cause the fleas would jump on me and bite me. Its terrible to visit someone who has fleas all over their home.